EU Missions 2026-27 Work Programme published

Applicants can now explore funding opportunities within the EU Missions for 2026 and 2027.

The Missions work programme in its entirety can be found here.

2026

Adaptation to Climate Change

Opening: 04 Feb 2026
Deadline: 23 Sep 2026

• HORIZON-MISS-2026-01-CLIMA-01:National Adaptation Hubs - Bringing together the national level with the engaged regional and local levels (multi-level governance)
• HORIZON-MISS-2026-01-CLIMA-02: Facilitating implementation of actionable solutions for climate adaptation of regions and local authorities
• HORIZON-MISS-2026-01-CLIMA-03: Standardising and supporting climate services for climate adaptation
• HORIZON-MISS-2026-01-CLIMA-04: Bridging the gap between disaster risk management and climate adaptation
• HORIZON-MISS-2026-01-CLIMA-05:Demonstrating solutions to protect and preserve cultural heritage from the impacts of climate change
• HORIZON-MISS-2026-01-CLIMA-06: Improving climate resilience of navigable inland waterways, their surroundings and related water infrastructure
• HORIZON-MISS-2026-01-CLIMA-07: Supporting financing of local adaptation actions with combination of public funding and private financing
• HORIZON-MISS-2026-06-CLIMA-SOIL: Joint demonstration of solutions to build soil resilience to extreme weather events and support food security

Cancer

Opening: 10 Feb 2026
Deadline: 15 Sep 2026

• HORIZON-MISS-2026-02-CANCER-01: Virtual Human Twin (VHT) Models for Cancer Research
• HORIZON-MISS-2026-02-CANCER-02: Microbiome for early cancer prediction before the onset of disease
• HORIZON-MISS-2026-02-CANCER-03: Pragmatic clinical trials to optimise immunotherapeutic interventions for patients with refractory cancers
• HORIZON-MISS-2026-02-CANCER-04: Earlier and more precise palliative care
• HORIZON-MISS-2026-02-CANCER-05: Boosting mental health of young cancer survivors through the European Cancer Patient Digital Centre (ECPDC)
• HORIZON-MISS-2026-02-CANCER-06: Development of a research capacity building programme on cancer with and for Ukraine
• HORIZON-MISS-2026-02-CANCER-07: Improve the Quality of Life of older cancer patients

Restore our Ocean and Waters

Opening: 04 Feb 2026
Deadline: 23 Sep 2026

• HORIZON-MISS-2026-03-OCEAN-01: Large-scale demonstration for mapping the distribution and condition of marine habitats to implement the Nature Restoration Regulation
• HORIZON-MISS-2026-03-OCEAN-02: Addressing aquatic pollution and biodiversity loss through nature positive solutions from source to sea
• HORIZON-MISS-2026-03-OCEAN-03: By fishers, for fishers: co-management of marine and freshwaters ecosystems and resources
• HORIZON-MISS-2026-03-OCEAN-04: Towards a European network of ocean technology testing sites
• HORIZON-MISS-2026-03-OCEAN-05: Regional (sea-basins) components of the EU Digital Twin Ocean

Climate-Neutral and Smart Cities 

Opening: 04 Feb 2026
Deadline: 08 Oct 2026

• HORIZON-MISS-2026-04-CIT-01: Energy efficient urban and sub-urban public transport, complemented by shared mobility
• HORIZON-MISS-2026-04-CIT-02: Transition to low-temperature heating solutions in multi-
  apartment buildings
• HORIZON-MISS-2026-04-CIT-NEB-B4P-CCRI-03: Introducing circular economy models in the construction sector, from buildings to city scale

Soil Deal for Europe

Opening: 04 Feb 2026
Deadline: 23 Sep 2026

• HORIZON-MISS-2026-05-SOIL-01: Monitoring soil health in practice: equipping stakeholders to sample, analyse, and interpret soil health indicators
• HORIZON-MISS-2026-05-SOIL-02: Antimicrobial resistance and antibiotic biosynthesis in soils: developing key understanding and counteractive strategies using a One-Health approach
• HORIZON-MISS-2026-05-SOIL-03: Enabling user-centred and open innovation initiatives to enhance oil health in Ukraine
• HORIZON-MISS-2026-05-SOIL-04: Leveraging long-term field experiments and other datasets to develop AI-ready decision support systems for sustainable soil management
• HORIZON-MISS-2026-06-CLIMA-SOIL: Joint demonstration of solutions to build soil resilience to extreme weather events and support food security

Opening: 12 Feb 2026
Deadline - First stage: 14 Apr 2026
Deadline - Second stage: 15 Sep 2026

• HORIZON-MISS-2026-05-SOIL-01-two-stage: Living labs to enhance soil health in Alpine and Atlantic biogeographical regions
• HORIZON-MISS-2026-05-SOIL-02-two-stage: Living labs to enhance soil health in managed forests and in natural/semi-natural lands

2027

Adaptation to Climate Change

Opening: 09 Feb 2027
Deadline: 21 Sep 2027

• HORIZON-MISS-2027-01-CLIMA-01: Demonstrating transformative solutions to increase cross-border climate resilience
• HORIZON-MISS-2027-01-CLIMA-02: Researching and applying the potential of Artificial Intelligence to foster climate resilience at the regional and local levels

Opening: 09 Feb 2027
Deadline(s): 22 Sep 2027

• HORIZON-MISS-2027-07-CLIMA-CIT-NEB-01: Urban nature: supporting restoration of urban ecosystems, along urban transport networks and in the built environment
• HORIZON-MISS-2027-07-CLIMA-CIT-CCRI-02: Deploying innovative wastewater management, treatment and valorisation solutions in European cities and regions in the context of climate change

Cancer

Opening: 10 Feb 2027
Deadline: 21 Sep 2027

• HORIZON-MISS-2027-02-CANCER-01: Leveraging functional genomics to reveal novel targets for cancer treatment
• HORIZON-MISS-2027-02-CANCER-02: Clinical research by Comprehensive Cancer Infrastructures for the benefit of patients with common cancers
• HORIZON-MISS-2027-02-CANCER-03: Phase 1 including first-in-human clinical trials to test biomarker-guided medicines or multi-modal treatment interventions for patients with rare or very rare cancers or cancer subtypes
• HORIZON-MISS-2027-02-CANCER-04: Improving equitable health outcomes and added value for and with cancer patients through health-economics research, health systems research and outcomes research
• HORIZON-MISS-2027-02-CANCER-05: Pre-commercial procurement of affordable solutions for healthcare systems in the areas of cancer technologies, cancer medical devices, or cancer medicines
• HORIZON-MISS-2027-02-CANCER-06: Support a Young Cancer Survivor Quality of Life (QoL) research programme by cancer charities and funding agencies

Opening: 04 Feb 2027
Deadline: 21 Sep 2027

• HORIZON-MISS-2027-06-SOIL-CANCER: Living labs to monitor and mitigate carcinogenic substances in and originating from soils: Evaluating their effects on human cancer risks

Restore our Ocean and Waters Mission

Opening: 09 Feb 2027
Deadline: 21 Sep 2027

• HORIZON-MISS-2027-03-OCEAN-01: Increasing riparian and coastal areas resilience to climate change, including in waterfront cities and islands
• HORIZON-MISS-2027-03-OCEAN-02: Circularity of seafood supply chain
• HORIZON-MISS-2027-03-OCEAN-03: Green, circular and resilient harbours
• HORIZON-MISS-2027-03-OCEAN-04: Towards community-driven business models: coastal and freshwaters sustainable tourism
• HORIZON-MISS-2027-03-OCEAN-05: Large-scale demonstration of protection, restoration and management of blue forest ecosystems in European sea basins

Climate-Neutral and Smart Cities

Opening: 09 Feb 2027
Deadline: 07 Oct 2027

• HORIZON-MISS-2027-04-CIT-01: Innovative microgrids for improved energy system integration and efficiency in urban contexts
• HORIZON-MISS-2027-04-CIT-02: Hydrogen cities
• HORIZON-MISS-2027-04-CIT-03: Inclusive and climate resilient multimodal passenger hubs enhancing modal shift towards sustainable transport and shared mobility
• HORIZON-MISS-2027-04-CIT-CCRI-04: Advancing circular logistics solutions in cities
• HORIZON-MISS-2027-04-CIT-05: Boosting the transformation towards climate-neutral
  cities, the net-zero economy and open strategic autonomy through Pre-Commercial Procurement (PCP)

Opening: 09 Feb 2027
Deadline: 22 Sep 2027

• HORIZON-MISS-2027-07-CLIMA-CIT-NEB-01: Urban nature: supporting restoration of urban ecosystems, along urban transport networks and in the built environment
• HORIZON-MISS-2027-07-CLIMA-CIT-CCRI-02: Deploying innovative wastewater management, treatment and valorisation solutions in European cities and regions in the context of climate change

Soil Deal for Europe

Opening: 04 Feb 2027
Deadline - First stage: 08 Apr 2027
Deadline - Second stage: 14 Sep 2027

• HORIZON-MISS-2027-05-SOIL-01-two-stage: Living labs to enhance soil health in Continental, Black Sea, Pannonian and Steppic biogeographical regions
• HORIZON-MISS-2027-05-SOIL-02-two-stage: Living Labs for co-creating solutions to reduce eutrophication from agriculture
• HORIZON-MISS-2027-05-SOIL-03-two-stage: Agroforestry for soil health at landscape level
• HORIZON-MISS-2027-05-SOIL-04-two-stage: Participatory research on the health of communities in contact with polluted soils
• HORIZON-MISS-2027-05-SOIL-05-two-stage: Innovative biotechnologies to restore soil health and improve agricultural competitiveness and resilience
• HORIZON-MISS-2027-05-SOIL-06-two-stage: Long-term drivers and consequences of soil degradation: learning from the past to improve future soil health

Opening: 04 Feb 2027
Deadline: 21 Sep 2027

• HORIZON-MISS-2027-06-SOIL-CANCER: Living labs to monitor and mitigate carcinogenic substances in and originating from soils: Evaluating their effects on human cancer risks