Prepublication: EU Missions Work Programme 2025

The pre-published work programme for the EU Missions is now available.

The draft has not been adopted  the European Commission. The adoption of the Horizon Europe ‘main’ work programme 2025 and the amended Horizon Europe ‘main’ work programme 2023-2025 is planned for May 2025.

The following topics are outlined in the pre-published Work Programme:

Adaptation to Climate Change

Opening: 06 May 2025
Deadline: 24 Sep 2025

• HORIZON-MISS-2025-01-CLIMA-01: Supporting regions and local authorities in assessing climate risk
• HORIZON-MISS-2025-01-CLIMA-02: Supporting regional and local authorities in developing their Action Plans towards climate resilience
• HORIZON-MISS-2025-01-CLIMA-03: Demonstrating solutions to help hotspots in coastal regions to adapt to climate change
• HORIZON-MISS-2025-01-CLIMA-04: Testing and demonstrating innovative solutions to improve resilience to extreme heat, including addressing health impacts
• HORIZON-MISS-2025-01-CLIMA-05: Better understanding incentives for private sector financing of adaptation solutions
• HORIZON-MISS-2025-01-CLIMA-06: Pre-commercial procurement of breakthrough solutions for climate proofing of public buildings

Cancer

Opening: 06 May 2025
Deadline: 16 Sep 2025

• HORIZON-MISS-2025-02-CANCER-01: Sustained collaboration of national and regional cancer funders to support the Cancer Mission through translational research
• HORIZON-MISS-2025-02-CANCER-02: Understanding the effects of environmental exposure on the risk of paediatric, adolescent and young adult cancers
• HORIZON-MISS-2025-02-CANCER-03: Innovative surgery as the cornerstone of affordable multi-modal therapeutic interventions benefitting cancer patients with locally advanced or metastatic disease
• HORIZON-MISS-2025-02-CANCER-04: Investigator-initiated multinational early-stage innovative clinical trials for paediatric cancer
• HORIZON-MISS-2025-02-CANCER-05: Pragmatic clinical trials to enhance the quality of life of older cancer patients (65 years and older) through nutrition
• HORIZON-MISS-2025-02-CANCER-06: Support to the network of National Cancer Mission Hubs (NCMHs)

Restore our Ocean and Waters

Opening: 07 May 2025
Deadline: 24 Sep 2025

• HORIZON-MISS-2025-03-OCEAN-01: Blue Parks - Towards a coherent European network of strictly proected areas for restoring healthy and productive marine ecosystems
• HORIZON-MISS-2025-03-OCEAN-02: A toolbox for public authorities to address marine plastics and liter from river-to-ocean
• HORIZON-MISS-2025-03-OCEAN-03: Digital technologies and energy transition in fisheries and/or aquaculture
• HORIZON-MISS-2025-03-OCEAN-04: Restoring Ocean and Waters in Regions
• HORIZON-MISS-2025-03-OCEAN-05: Restoring Ocean and Waters in waterfront Cities and their Ports
• HORIZON-MISS-2025-03-OCEAN-06: Restoring Ocean and Waters on Islands
• HORIZON-MISS-2025-03-OCEAN-07: Mission Lighthouses coordination and support activities
• HORIZON-MISS-2025-03-OCEAN-08: EU Digital Twin Ocean: Contribution to the EU DTO core infrastrucure through applications for sustainable ocean management

100 Climate-Neutral and Smart Cities by 2030

Opening: 06 May 2025
Deadline: 04 Sep 2025

• HORIZON-MISS-2025-04-CIT-01: Coupling circularity and climate mitigation in industrial sites and their cities and regions
• HORIZON-MISS-2025-04-CIT-02: Innovative, AI-based solutions for urban planning and management

Deadline: 20 Jan 2026

• HORIZON-MISS-2026-04-PCP-CIT-01: Boosting the transformation towards climate-neutral cities, the net-zero economy and open strategic autonomy through Pre-Commercial Procurement (PCP) 

A Soil Deal for Europe

Opening: 06 May 2025
Single stage - Deadline: 30 Sep 2025

• HORIZON-MISS-2025-05-SOIL-01: Living Labs for soil remediation and green redevelopment of brownfields (30 Sep 2025)
• HORIZON-MISS-2025-05-SOIL-02: Social, economic and cultural drivers, and costs of land degradation
• HORIZON-MISS-2025-05-SOIL-03: Increasing environmental resilience through a better knowledge and management of the soil-water nexus
• HORIZON-MISS-2025-05-SOIL-04: Developing transfer functions for the Soil Monitoring Law
• HORIZON-MISS-2025-05-SOIL-05: EU global footprint on soils
• HORIZON-MISS-2025-05-SOIL-06: Quantifying the impact of farming practices on soil health in arable lands
• HORIZON-MISS-2025-05-SOIL-07: Improved land suitability for soil health and sustainable biomass production
• HORIZON-MISS-2025-05-SOIL-08: Support to the operation and further development of soil-health science-policy interfaces and national soil-health hubs
• HORIZON-MISS-2025-05-SOIL-09: Citizen engagement for sustainable land management through local and regional authorities
• HORIZON-MISS-2025-05-SOIL-10: Network on carbon farming and emissions reductions for agricultural and forest lands
• HORIZON-MISS-2025-05-SOIL-11: Soil Salinity in Europe: Drivers, indicators, current levels and temporal changes

Two stage - Deadlines:  04 Sep 2025 (First Stage), 18 Feb 2026 (Second Stage)

• HORIZON-MISS-2025-05-SOIL-01-two-stage: Living labs to enhance soil health in Continental, Boreal and Alpine biogeographical regions
• HORIZON-MISS-2025-05-SOIL-02-two-stage: Broadening the living labs approach for soil health in Africa and Latin America and the Caribbean (LAC)

EU Missions' Joint Calls

Opening: 06 May 2025
Deadline: 04 Sep 2025

• HORIZON-MISS-2025-06-CIT-CANCER-01: Increasing walking and cycling: to reap health benefits, emission reductions and integrate active mobility and micro-mobility devices, with smart technologies and infrastructure

EU Missions' Cross-cutting activities

Opening: 09 Dec 2025
Deadline: 31 Mar 2026

• HORIZON-MISS-2026-07-CROSS-01: Strengthening skills and capacity for the deployment of EU Missions
• HORIZON-MISS-2026-07-CROSS-02: Understanding and overcoming barriers to the scale-up of innovations supporting EU Missions
• HORIZON-MISS-2026-07-CROSS-03: Advancing lead markets and proof-of-concept for deep tech solutions contributing to EU Missions

More information about the Horizon Europe work programmes, including the pre-published 2025 work programmes, can be found on the European Commission's website.

European Commission: Horizon Europe work programmes